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The ProteinALIGNment (Pdb) programs are a set of programs for sequence searches. They can perform standard dynamic programming, heuristic fasta like searches and profile-profile alignments. Unfortunately the package is not very well documented, but is all available for free under a GPL like license. Pdb can be used for many type of alignment problems, it is certainly not always the fastest of all programs but it is very flexible. This webservice can 1. Align two sequences with default values 2) Align two sequences with nonDefault parameters 3) Align two sequences and include their secondary structure information 4) Align a sequence and a structure and get the alignment and a CA-pdb-file 5) Align a sequence and a profile 6) Align two profiles.