European Bioinformatics Institute (EBI)

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Hamish McWilliam (9 months ago)

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Documentation URL(s): Hamish McWilliam (9 months ago)

Login to add a documentation URL Description(s): Hamish McWilliam (9 months ago)Position Specific Iterative BLAST (PSI-BLAST) refers to a feature of NCBI BLAST 2.0 in which a position-specific scoring matrix (PSSM) profile is constructed from set of BLAST alignments. The PSSM is then used to search the database in subsequent iterations allowing the detection of distant evolutionary relationships.

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Login to add cost info Usage Conditions: Hamish McWilliam (2 months ago)E-mail supplied for submission must be a valid e-mail address and no more than 25 concurrent jobs should be submitted at any one time, see and the EMBL-EBI Terms of Use:

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Login to add contact info Publications: for this service. This can be a URI to the publication and/or a DOI. Hamish McWilliam (2 months ago)Goujon M., McWilliam H., Li W., Valentin F., Squizzato S., Paern J. and Lopez R. (2010)
“A new bioinformatics analysis tools framework at EMBL-EBI.”
Nucleic Acids Res. 38:W695-9
PMID: 20439314 <;=MED>
DOI: 10.1093/nar/gkq313 <>

Hamish McWilliam (2 months ago)Altschul S.F., Madden T.L., Schaffer A.A., Zhang J., Zhang Z., Miller W. and Lipman D.J. (1997)
“Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.”
Nucleic Acids Res. 25(17):3389-402.
PMID: 9254694 <;=MED>
DOI: 10.1093/nar/25.17.3389 <>

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