Web Service Primary T cell REST Us

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Bennie GeorgeUs (2 months ago)

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by Bennie George (2 months ago)

The success of genome editing in primary T cell robustly promotes the development of CAR-T immunotherapy. In CAR-T cells, CAR gene can be delivered to a specific site within the genome by CRISPR/Cas9. Using CRISPR/Cas9 system reduces the risk of gene insertion at incorrect or undesired location. Meanwhile, CRISPR/Cas9 technology is used to knock out endogenous T cell receptor (TCR) and HLA class I (HLA-I) for reducing unwanted graft-versus-host reactivity.

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