Web Service hERG Safety Assay REST

aka Herg test | Creative Bioarray aka hERG Safety Assay | Creative Bioarray Add_annotation_inactiveAdd_annotation_inactiveLog in to add alternative_name
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Annotations: 8 Total number of annotations from the provider's definition / description document. 0 Total number of annotations submitted by members of BioCatalogue. 8 Total number of annotations sourced from other registries. 0

Overview

Provider:
www-creative-bioarray-com

Location:
not available

Submitter/Source:
Bennie GeorgeUs (20 days ago)

Base URL:
https://www.creative-bioarray.com/Services/hERG-Safety.htm

Description(s):
by Bennie George (20 days ago)

ICH S7B guideline1 regulates in vitro IKr assay (such as hERG safety assay) and in vitro QT assay for identifying and assessing the potential of a test compound to delay ventricular repolarization. Ventricular repolarization is a complex physiological process determined by the duration of the cardiac action potential. It is the net result of the activities of many highly interdependent membrane ion channels and transporters. Many compounds can affect the activities of the ion channels or transporters, thus have the potential of delaying the ventricular repolarization and leading to prolonged QT interval.

by Bennie George (20 days ago)

Staffed with a group of experts that have gained years of experience in ion channel safety assays and cardiotoxicity assessment, Creative Bioarray offers hERG safety assay in accordance with the ICH S7B guideline to evaluate compound cardiovascular safety and to support drug development. Inhibition assays of other ion channels are also available.

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