Web Service Human P2RY2/Galpha15 Stable Cell Line-1321N1 REST Us

aka Stable Cell Line Add_annotation_inactiveAdd_annotation_inactiveLog in to add alternative_name
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Annotations: 4 Total number of annotations from the provider's definition / description document. 0 Total number of annotations submitted by members of BioCatalogue. 4 Total number of annotations sourced from other registries. 0

Overview

Provider:
www-creative-bioarray-com

Location:
United States Us

Submitter/Source:
Bennie GeorgeUs (4 months ago)

Base URL:
https://www.creative-bioarray.com/acroscell/human-p2ry2-galpha15-stable-cell-line-1321n1-acc-rg0724-item-515.htm

Documentation URL(s):
None
Description(s):
by Bennie George (4 months ago)

The P2Y GPCRs serve as receptors for extracellular nucleotides. P2Y2 (also known as P2U) is activated by UTP and ATP, and couples to Gq to increase intracellular calcium. The P2Y2 receptor knockout mouse displays defective nucleotide-stimulated Cl-secretion, and a P2Y2 selective agonist increases tracheal epithelial chloride and water secretion. As a result, P2Y2 is a potential target for treatment of cystic fibrosis. In addition, the P2Y2 KO mouse displays salt-resistant hypertension.

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