Web Service Human P2RY4/Clytin Stable Cell Line-1321N1 REST Us

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Bennie GeorgeUs (10 months ago)

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by Bennie George (10 months ago)

The P2Y GPCRs serve as receptors for extracellular nucleotides. The P2Y4 receptor is activated by UTP, and also by ATP in rodents, and couples to Gq to increase intracellular calcium. P2Y4 is expressed prominently in the intestinal epithelium, where it regulates intestinal chloride secretion. P2Y4 therefore is likely to be involved in infectious diarrhea caused by nucleotides released upon infection with enteropathogenic bacteria.

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