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Norepinephrine is implicated in a wide range of physiological processes through activation of nine different G-protein-coupled receptors (alpha1a, alpha1b, alpha1d, alpha2a, alpha2b, alpha2c, beta1, beta2, beta3). The alpha1B-adrenoceptor expresses in brain, heart, kidney, and artery of various mammalian species and mediate diverse effects on cardiac functions, muscle contractions and cell growth.