Provider:
www-creative-bioarray-com
Location:
United States
Submitter/Source:
Bennie George (28 days ago)
Base URL:
https://www.creative-bioarray.com/acroscell/human-ptgdr2-beta-arrestin-stable-cell-line-cho-acc-rg1458-item-893.htm
Documentation URL(s): None Login to add a documentation URL Description(s): Bennie George(28 days ago)
The chemoattractant-homologous receptor expressed on TH2 cells (CRTH2, also known as DP2 and GPR44) serves as a receptor for prostaglandin D2 (PGD2) and has been reported to mediate PGD2-dependent migration of eosinophils. DP2 mediates the pro-inflammatory effects of PGD2 generated in allergic inflammation. 11-Dehydrothromboxane B2 (11-dehydro-TXB2) was found to be a full agonist of the DP2 receptor and hence might cause the receptor activation in cellular contexts where PGD-synthase is not present. Antagonism of the 11-dehydro-TXB2/DP2 axis may be of therapeutic relevance.
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