Human CXCR2/beta-Arrestin Stable Cell Line-CHO REST

Provider:
www-creative-bioarray-com

Location:
United States

Submitter/Source:
Bennie George (27 days ago)

Base URL:
https://www.creative-bioarray.com/acroscell/human-cxcr2-beta-arrestin-stable-cell-line-cho-acc-rg1463-item-898.htm

Documentation URL(s): None Login to add a documentation URL Description(s): Bennie George(27 days ago)

CXCR2 (high affinity interleukin-8 receptor B, IL8RB) is a receptor to interleukin-8, which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This receptor also binds to GRO/MGSA and NAP-2 with high affinity. Some highly potent small molecule antagonists of CXCR2 showed success in blocking in vivo trafficking of neutrophils, suggesting that antagonism of IL-8 at the receptor level is a viable therapeutic strategy in conditions such as pulmonary disease.

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