Rat Chrm4 Stable Cell Line-CHO REST

Provider:
www-creative-bioarray-com

Location:
United States

Submitter/Source:
Bennie George (16 days ago)

Base URL:
https://www.creative-bioarray.com/acroscell/rat-chrm4-stable-cell-line-cho-acc-ri0151-item-61.htm

Documentation URL(s): Bennie George (16 days ago) https://www.creative-bioarray.com/acroscell/rat-chrm4-stable-cell-line-cho-acc-ri0151-item-61.htm Login to add a documentation URL Description(s): Bennie George(16 days ago)

Muscarinic acetylcholine receptors are relatively abundant and mediate many of the diverse actions of acetylcholine in the CNS, as well as throughout non-nervous tissues innervated by the parasympathetic nervous system. There are five muscarinic receptor subtypes referred to as M1, M2, M3, M4 and M5 which belong to GPCR superfamily. The odd-numbered muscarinic receptors (M1, M3, M5) couple efficiently through Gq/11, to activate of phospholipase C, that initiates the phosphatidylinositol turnover response. The even-numbered muscarinic receptors (M2, M4) inhibit adenylyl caclase activity via activation of the Gi class of G proteins. M2 and M4 receptors also activate G protein-coupled potassium channel, which leads to hyperpolarization of the plasma membrane of excitable cells.

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