Web Service Human KCNQ3/KCNQ5 Stable Cell Line-HEK293 REST Us

aka Human KCNQ3/KCNQ5 Stable Cell Line-HEK293 Add_annotation_inactiveAdd_annotation_inactiveLog in to add alternative_name
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Annotations: 5 Total number of annotations from the provider's definition / description document. 0 Total number of annotations submitted by members of BioCatalogue. 5 Total number of annotations sourced from other registries. 0

Overview

Provider:
www-creative-bioarray-com

Location:
United States Us

Submitter/Source:
Bennie GeorgeUs (16 days ago)

Base URL:
https://www.creative-bioarray.com/acroscell/human-kcnq3-kcnq5-stable-cell-line-hek293-acc-ri0147-item-63.htm

Description(s):
by Bennie George (16 days ago)

The human KCNQ3 and KCNQ5 genes encode the pore-forming subunits of Kv7.3 and Kv7.5, respectively. These subunits form heteromeric voltage-gated potassium channels that underlie M-current that regulates repetitive activity in neurons. Mutations in KCNQ3 that reduce M-current are responsible for some forms of benign familial neonatal seizure. Kv7.3/Kv7.5 channels expressed in neurons are therapeutic targets in seizure and cognitive impairment.

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