GeneSilico

Description(s): jerzyo (about 1 year ago)Our group combines theoretical and experimental analysis of proteins, in particular enzymes that act on DNA or RNA.

We study the rules that govern the sequence-structure-function relationships in proteins and use the acquired knowledge to predict structures and functions for uncharacterized open reading frames and to alter the function of known proteins and engineer new enzymes.

Our key strength is in the integration of various types of theoretical and experimental analyses. We develop and use computer programs for modeling of protein three-dimensional structures based on heterogenous, low-resolution, noisy and ambivalent experimental data. We are also involved in genome-scale phylogenetic analyses, with the focus on identification of proteins that belong to particular families. Subsequently, we characterize experimentally the function of the most interesting new genes/proteins identified by bioinformatics. We also use theoretical predictions to guide protein engineering, using rational and random approaches. Our ultimate goal is to identify complete sets of enzymes involved in particular metabolic pathways (e.g. RNA modification, DNA repair) and to design proteins with new properties, in particular enzymes with new useful functions, which have not been observed in the nature.

We are well-equipped with respect to both theoretical and experimental analyses. Our lab offer excellent environment for training of young researchers in both bioinformatics and molecular biology/biochemistry of protein-nucleic acid interactions.

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Website(s): jerzyo (about 1 year ago)www.genesilico.pl

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Contact Info: jerzyo (about 1 year ago)iamb@genesilico.pl

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