Member of BioCatalogue Bennie George

Services Annotated (21)

Human P2RY1/Galpha15 Stable Cell Line-1321N1 REST Us
PASSED
P2Y1 is a GPCR that binds to ADP and ATP to activate Gq. A wide variety of cells and tissues express P2Y1. Vascular endothelium and smooth muscle express P2Y1, and mediate vascular tone both in the resting state and in thrombosis, when platelet-derived ATP and ADP are present at high concentrations. In addition, activation of P2Y1 expressed on platelets leads to ADP-induced shape changes and aggregation.

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Human P2RY1/Clytin Stable Cell Line-1321N1 REST Us
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PASSED
P2Y1 is a GPCR that binds to ADP and ATP, and couples to activate Gq. A wide variety of cells and tissues express P2Y1. Vascular endothelium and smooth muscle cells express P2Y1, and mediate vascular tone both in the resting state and in thrombosis, when platelet-derived ATP and ADP are present at high local concentrations. In addition, activation of P2Y1 expressed on platelets leads to ADP-induced shape changes and aggregation.

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Human P2RY11/Galpha15 Stable Cell Line-1321N1 REST Us
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The P2Y GPCRs serve as receptors for extracellular nucleotides. P2Y is a relatively low affinity receptor for ATP present humans but not rodents. It is unique among P2Y receptors in increasing both cAMP and calcium levels. P2Y is expressed in immune cells, and it mediates dendritic cell maturation induced by ATP. In addition to ATP, NAD+ and NADP+ bind and activate P2Y in granulocytes. An alternate form of P2Y, in which the second exon of P2Y1 undergoes intergenic splicing with exon 12 of the...

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Human P2RY11/Clytin Stable Cell Line-1321N1 REST Us
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The P2Y GPCRs serve as receptors for extracellular nucleotides. P2Y11 is a relatively low affinity receptor for ATP present humans but not rodents. It is unique among P2Y receptors in increasing both cAMP and calcium levels. P2Y11 is expressed in immune cells, and it mediates dendritic cell maturation induced by ATP. In addition to ATP, NAD+ and NADP+ bind and activate P2Y11 in granulocytes. An alternate form of P2Y11, in which the second exon of P2Y11 undergoes intergenic splicing with exon ...

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Human P2RY12/Galpha15 Stable Cell Line-U2OS REST Us
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P2Y12 is a Gi-coupled 7TM receptor belonging to the P2Y family of nucleotide receptors. The principle ligand for P2Y12 in vivo is ADP, although it binds with lesser affinity to ATP. P2Y12 is expressed predominantly in platelets, where it mediates ADP-induced stable aggregation and secretion. The antithrombotic drugs clopidogrel and ticlopidine disrupt P2Y12-mediated platelet aggregation, and are indicated in acute coronary syndromes. However, metabolites of each drug that are generated by hep...

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Human P2RY12/Clytin Stable Cell Line-1321N1 REST Us
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PASSED
P2Y12 is a Gi-coupled 7TM receptor belonging to the P2Y family of nucleotide receptors. The principle ligand for P2Y12 in vivo is ADP, although it binds with lesser affinity to ATP. P2Y12 is expressed predominantly in platelets, where it mediates ADP-induced stable aggregation and secretion. The antithrombotic drugs clopidogrel and ticlopidine disrupt P2Y12-mediated platelet aggregation, and are indicated in acute coronary syndromes. However, metabolites of each drug that are generated by hep...

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Human P2RY2/Galpha15 Stable Cell Line-1321N1 REST Us
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PASSED
The P2Y GPCRs serve as receptors for extracellular nucleotides. P2Y2 (also known as P2U) is activated by UTP and ATP, and couples to Gq to increase intracellular calcium. The P2Y2 receptor knockout mouse displays defective nucleotide-stimulated Cl-secretion, and a P2Y2 selective agonist increases tracheal epithelial chloride and water secretion. As a result, P2Y2 is a potential target for treatment of cystic fibrosis. In addition, the P2Y2 KO mouse displays salt-resistant hypertension.

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Human P2RY2/Clytin Stable Cell Line-1321N1 REST Us
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PASSED
The P2Y GPCRs serve as receptors for extracellular nucleotides. P2Y2 (also known as P2U) is activated by UTP and ATP, and couples to Gq to increase intracellular calcium. The P2Y2 receptor knockout mouse displays defective nucleotide-stimulated Cl-secretion, and a P2Y2 selective agonist increases tracheal epithelial chloride and mucin secretion in dog tracheal epithelium and cultured human airway epithelium, respectively. As a result, P2Y2 is a potential target for treatment of cystic fibrosi...

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Human P2RY4/Galpha15 Stable Cell Line-1321N1 REST Us
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PASSED
The P2Y GPCRs serve as receptors for extracellular nucleotides. The P2Y4 receptor is activated by UTP, and also by ATP in rodents, and couples to Gq to increase intracellular calcium. P2Y4 is expressed prominently in the intestinal epithelium, where it regulates intestinal chloride secretion. P2Y4 therefore is likely to be involved in infectious diarrhea caused by nucleotides released upon infection with enteropathogenic bacteria.

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Human P2RY4/Clytin Stable Cell Line-1321N1 REST Us
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PASSED
The P2Y GPCRs serve as receptors for extracellular nucleotides. The P2Y4 receptor is activated by UTP, and also by ATP in rodents, and couples to Gq to increase intracellular calcium. P2Y4 is expressed prominently in the intestinal epithelium, where it regulates intestinal chloride secretion. P2Y4 therefore is likely to be involved in infectious diarrhea caused by nucleotides released upon infection with enteropathogenic bacteria.

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Human QRFPR/Galpha15 Stable Cell Line-Chem-1 REST Us
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GPR103 is a Gq-coupled receptor that is located in the brain and adrenal gland, and is activated by a 43-amino acid RFamide peptide, QRFP43, and a 26 amino acid fragment, QRFP26/26RFa/Peptide 518. QRFP43 is the active form in rat brain, and intracerebral administration of QRFP43 induces feeding and metabolic rate.

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Human PTAFR/Galpha15 Stable Cell Line-Chem-1 REST Us
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Platelet-activating factor (PAF) is a bioactive phospholipid that was originally characterized by its ability to induce platelet aggregation, but was subsequently shown to mediate angiogenesis, inflammation and neural development. The PAF receptor is a G protein coupled receptor that signals through multiple pathways and mediates several cellular responses including cell motility, smooth muscle contraction, and cytokine and leukotriene release.

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Human PROKR1/Galpha15 Stable Cell Line-Chem-1 REST Us
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Prokineticins, also known as endocrine gland vascular endothelial growth factors (EG-VEGF), are two approximately 10 kD secreted proteins originally described to mediate angiogenesis and gastrointestinal smooth muscle contraction. Subsequently, prokineticins have been found to mediate central nervous system functions including circadian rhythms and olfactory bulb development. Two Gq-coupled receptors, PK1 and PK2 (also known as GPR73a and GPR73b), mediate cellular responses to prokineticins.

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Human PROKR2/Galpha15 Stable Cell Line-Chem-1 REST Us
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Prokineticins, also known as endocrine gland vascular endothelial growth factors (EG-VEGF), are two approximately 10 kD secreted proteins originally described to mediate angiogenesis and gastrointestinal smooth muscle contraction. Subsequently, prokineticins have been found to mediate central nervous system functions including circadian rhythms and olfactory bulb development. Two Gq-coupled receptors, PK1 and PK2, mediate cellular responses to prokineticins. The phenotype of the PK2-null mous...

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Human PRLHR/Galpha15 Stable Cell Line-Chem-1 REST Us
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PRP, encoded by the GPR10 (or hGR3) gene, is a Gq-coupled receptor for prolactin-releasing peptide that is expressed in the pituitary. Genetic studies in rodents indicate that lack of GPR10 leads to hyperphagia, obesity and dyslipidemia. In humans, genetic variations in GPR10 are associated with lowered blood pressure.

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Human PTGDR/Galpha15 Stable Cell Line-Chem-1 REST Us
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Prostanoids are a series of arachidonic acid metabolites produced by the action of cyclooxygenase and subsequently by isomerases and synthases. Cells rapidly secrete prostanoids after synthesis, whereupon the prostanoids bind to a family of 8 GPCRs to exert their biological effects. The prostaglandin PGD2 is produced by mast cells upon activation by allergens, and is present at high levels in allergic diseases. PGD2 binds to two receptors, DP and CRTH2. DP activates Gs to increase cAMP levels...

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Human PTGDR/Clytin Stable Cell Line-HEK293 REST Us
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Prostanoids are a series of arachidonic acid metabolites produced by the action of cyclooxygenase and subsequently by isomerases and synthases. Cells rapidly secrete prostanoids after synthesis, whereupon the prostanoids bind to a family of 8 GPCRs to exert their biological effects. The prostaglandin PGD2 is produced by mast cells upon activation by allergens, and is present at high levels in allergic diseases. PGD2 binds to two receptors, DP and CRTH2. DP activates Gs to increase cAMP levels...

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Rat O3far1-FLAG Stable Cell Line-HEK293T REST Us
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GPR120 is a G protein-coupled receptor for the long-chain free fatty acids. GPR120 mediated calcium mobilization, Erk1/Erk2 activation and GLP1 secretion. Unsaturated long-chain FFAs had a dose-dependent stimulatory effect, and alpha-linolenic acid was the most potent. GPR120 and GLP1 colocalized in human colonic intraepithelial neuroendocrine cells, and GPR120 may mediate dietary FFAstimulated GLP1 secretion.

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Human O3FAR1-FLAG Stable Cell Line-HEK293T REST Us
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GPR120 is a G protein-coupled receptor for the long-chain free fatty acids. GPR120 mediated calcium mobilization, Erk1/Erk2 activation and GLP1 secretion. Unsaturated long-chain FFAs had a dose-dependent stimulatory effect, and alpha-linolenic acid was the most potent. GPR120 and GLP1 colocalized in human colonic intraepithelial neuroendocrine cells, and GPR120 may mediate dietary FFA-stimulated GLP1 secretion.

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Human O3FAR1-FLAG Stable Cell Line-CHO REST Us
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GPR120 is a G-protein coupled receptor and has been shown to stimulate secretion of gut hormones GLP-1 and cholecystokinin upon binding of long chain free fatty acids. Stimulation of GPR120 by FFAs results in elevation of Ca2+ and activation of the ERK cascade which suggests interaction with the Gq family of G proteins. GPR120 is expressed in adipose tissue, proinflammatory macrophages and Kupffer cells. Stimulation of GPR120 with agonist causes broad anti-inflammatory effects in macrophages ...

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Human ANKRD39 adenoviral particles REST Us
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Cat.No.AD01056Z DescriptionAdenovirus with ORF of ankyrin repeat domain 39 (ANKRD39) with C terminal Flag and His tag. InsertANKRD39 Product TypeAdenoviral particle ShippingDry ice

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