Member of BioCatalogue Bennie George

Human CALCR Stable Cell Line-HEK293 REST Us
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This gene encodes a high affinity receptor for the peptide hormone Calcitonin and belongs to a subfamily of seven transmembrane spanning G protein coupled receptors. The protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants.

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Human CRHR2 Stable Cell Line-HEK293 REST Us
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Corticotropin Releasing Hormone Repceptor 2 is the gene that encodes a protein also known as CRHR-2. The Corticotropin Releasing Hormone Receptor family is a group of Gcoupled receptors that shows high affinity for Corticotropin Releasing Hormone (CRH). CRH is a polypeptide hormone and neurotransmitter synthesized in the hypothalamus that is the principal neuroregulator of the hypothalamic-pituitaryadrenocortical axis.

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Human FSHR Stable Cell Line-HEK293 REST Us
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Follicle stimulating hormone receptor belongs to a family of G-protein coupled receptors which activate adenylate cyclase. FSHR is a transmembrane receptor that interacts with the follicle stimulating hormone(FSH). In the ovary, the FSH receptor is necessary for follicular development and it is expressed on the granulosa cells. In the male, the FSH receptor has been identified on the Sertoli cells that are critical for spermatogenesis. Mutations in this gene cause ovarian dysgenesis type 1, a...

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Human ADCYAP1R1 Stable Cell Line-HEK293 REST Us
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Pituitary adenylate cyclase-activating polypeptide type I receptor, also known as PAC1 is a protein that in humans is encoded by the ADCYAP1R1 gene. ADCYAP1R1 is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor binds pituitary adenylate cyclase activating peptide (PACAP) mediating several biological activities and it is positively coupled to adenylate cyclase. ADCYAP1R1 is expressed in the adrenal medulla, pancr...

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Human ADRA1A Stable Cell Line-U2OS REST Us
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Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins. The alpha-adrenergic receptor (AR) subtypes (alpha(1a), alpha(1b), and alpha(1d)) mediate some physiological effects of epinephrine and norepinephrine.

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Human TACR2 Stable Cell Line-U2OS REST Us
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Tachykinin receptor 2 is the gene that encodes a protein that is one of the three Tachykinin receptors (TACRs), also termed NKRs. The Tachykinin receptor family is a group of G-coupled receptors whose principal ligands are the Neurokinins. TACR2 has been involved in stress induced hippocampal acetylcholine release and it is thought to be related with Alzheimer"s disease (AD).

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Human CHRM3 Stable Cell Line-U2OS REST Us
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Muscarinic acetylcholine receptors are G protein-coupled receptors. M1, M3, M5 receptors couple to G proteins of the Gq/11 family, which activate phospholipase C. M2 and M4 receptors couple to Gi/o-type G proteins that inhibit adenylyl cyclase activity.Muscarinic receptors control many effects of acetylcholine in the central and peripheral nervous system. M3 receptor is found in smooth muscles, the endocrine glands, the exocrine glands, as well as the lungs. It is also found in the CNS, where...

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Human CHRM5 Stable Cell Line-U2OS REST Us
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Muscarinic acetylcholine receptors are G protein-coupled receptors. M1, M3, M5 receptors couple to G proteins of the Gq/11 family, which activate phospholipase C. M2 and M4 receptors couple to Gi/o-type G proteins that inhibit adenylyl cyclase activity. Muscarinic receptors control many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor have not been fully explored; however, stimulation of this receptor is known to effectively dec...

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Human TACR3 Stable Cell Line-U2OS REST Us
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Tachykinin receptor 3 is the gene that encodes a protein that is one of the three Tachykinin receptors (TACRs), also termed NKRs. The Tachykinin receptor family is a group of G-coupled receptors whose principal ligands are the Neurokinins. TACR3 is distributed throughout the CNS and it is found in high levels in the cerebral cortex, basal ganglia and dorsal horn of the spinal cord. TACR3 ligands are used in clinical trials for treatment of schizophrenia and other indications.

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Human TACR1 Stable Cell Line-HEK293 REST Us
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Tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) belongs to a family of proteins characterized by the interaction with G proteins. TACR1 is localized both in the central nervous system (CNS) and peripheral tissues. Tachykinin receptor 1 presents great affinity for Substance P agonist. This receptor is an interesting drug target in the studies about analgesics and antidepressants.

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Human KCNA4 Stable Cell Line-HEK293 REST Us
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The human KCNA4 gene encodes the pore-forming subunit of Kv1.4, a voltage-gated potassium channel. Kv1.4 channels expressed in neurons are therapeutic targets in neuropathic pain.

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Human KCNA5 Stable Cell Line-HEK293 REST Us
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The human KCNA5 gene encodes the pore-forming subunit of Kv1.5, a voltage-gated potassium channel. A KCNA5 mutation has been linked to an inherited form of atrial fibrillation. Kv1.5 channels are widely expressed in heart, colon, kidney, vascular smooth muscle and CNS, and are therapeutic targets in atrial fibrillation, pulmonary hypertension, cancer, and multiple sclerosis.

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Human KCNA7 Stable Cell Line-HEK293 REST Us
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Kv1.7 is a voltage-gated, K+-selective channel expressed in the placenta, amnion, skeletal muscle, and pulmonary artery.

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Human KCNH2 Stable Cell Line-HEK293 REST Us
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The human KCNH2 gene encodes the pore-forming subunit of Kv11.1, the voltage-gated hERG potassium channel. HERG channels are upregulated in some types of cancer and may serve as a tumor marker. KCNH2 mutations cause inherited forms of cardiac disorders including both long QT (loss-of-function) and short QT (gain-of-function) syndromes. Inhibition of HERG channels by pharmaceuticals is the primary cause of acquired long QT syndrome and drug-induced torsade de pointe. Therefore, HERG is an anti...

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Human KCNH2 Stable Cell Line-CHO REST Us
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The human KCNH2 gene encodes the pore-forming subunit of Kv11.1, the voltage-gated hERG potassium channel. HERG channels are upregulated in some types of cancer and may serve as a tumor marker. KCNH2 mutations cause inherited forms of cardiac disorders including both long QT (loss-of-function) and short QT (gain-of-function) syndromes. Inhibition of HERG channels by pharmaceuticals is the primary cause of acquired long QT syndrome and drug-induced torsade de pointe. Therefore, HERG is an anti...

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Human KCNC4 Stable Cell Line-HEK293 REST Us
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The human KCNC4 gene encodes the pore-forming subunit of Kv3.4, a voltage-gated potassium channel expressed in the CNS, parathryroid gland, skeletal muscle, and pancreas. Kv3.4 channel expression is upregulated in Alzheimer"s disease and presents potential therapeutic target in Alzheimer's disease.

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Human KCND2/KCNIP2 Stable Cell Line-HEK293 REST Us
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The human KCND2 gene encodes the pore-forming subunit of Kv4.2, a voltage-gated potassium channel. The KCNIP2 gene encodes an auxiliary subunit of the channel. Kv4.2/KChIP2.2 channels expressed in neurons are therapeutic targets in nociceptive and inflammatory pain.

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Human KCND3 Stable Cell Line-CHO REST Us
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The human KCND3 gene encodes the pore-forming subunit of Kv4.3, a voltage-gated potassium channel. Kv4.3 channels expressed in heart are therapeutic targets in atrial fibrillation.

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Human KCND3 Stable Cell Line-HEK293 REST Us
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The human KCND3 gene encodes the pore-forming subunit of Kv4.3, a voltage-gated potassium channel. Kv4.3 channels expressed in heart are therapeutic targets in atrial fibrillation

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Human KCND3/KCNIP2 Stable Cell Line-CHO REST Us
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The human KCND3 gene encodes the pore-forming subunit of Kv4.3, a voltage-gated potassium channel. KCNIP2 encodes an auxiliary subunit of the channel. Kv4.3/KChIP2.2 channels expressed in heart are therapeutic targets in atrial fibrillation.

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Human KCNQ1/KCNE1 Stable Cell Line-CHO REST Us
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The human KCNQ1 gene encodes the pore-forming subunit of Kv7.1, a voltage-gated potassium channel. KCNE1 encodes an auxiliary subunit that modulates gating and pharmacological characteristics. Kv7.1/KCNE1 channels expressed in heart are safety targets in cardiac long-QT risk assessment.

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