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Human ADRB2-FLAG Stable Cell Line-CHO REST Us
Categories:
PASSED
Norepinephrine is implicated in a wide range of physiological processes through activation of nine different G-protein-coupled receptors (alpha1a, alpha1b, alpha1d, alpha2a, alpha2b, alpha2c, beta1, beta2, beta3). The human beta2-adrenergic receptor was the first 7-transmembrane receptor for a hormone or neurotransmitter to have its crystal structure solved. It has been suggested that the beta 2-adrenoceptor may form homodimers as well as oligomers with other receptors.

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Human ADRB1-FLAG Stable Cell Line-CHO REST Us
Categories:
PASSED
Norepinephrine is implicated in a wide range of physiological processes through activation of nine different G-protein-coupled receptors (alpha1a, alpha1b, alpha1d, alpha2a, alpha2b, alpha2c, beta1, beta2, beta3). The human beta1-adrenergic receptor is a 477–amino acid protein found in various heart and brain tissues. beta1 has an important role in the contractile action of valves in cardiac and digestive systems.

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Human ADRA2C-FLAG Stable Cell Line-CHO REST Us
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PASSED
The human adrenergic alpha2c receptor is a 458-amino acid, 7-transmembrane protein. It belongs to the group of nine adrenoceptors that mediate the biological actions of the endogenous catecholamines adrenaline and noradrenaline. All three alpha2-receptor subtypes may operate as presynaptic inhibitory feedback receptors to control the release of neurotransmitters.

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Human ADRA2B-FLAG Stable Cell Line-CHO REST Us
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PASSED
Adrenergic alpha2b receptor belongs to the group of nine adrenoceptors that mediate the biological actions of the endogenous catecholamines adrenaline and noradrenaline. While alpha2a receptor exerts a tonic sympathoinhibitory function, the alpha2b is responsible for the central hypertensive sympathoexcitatory response.

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Human ADRA2A-FLAG Stable Cell Line-CHO REST Us
Categories:
PASSED
Adrenergic alpha2a receptor belongs to the group of nine adrenoceptors that mediate the biological actions of adrenaline and noradrenaline. The alpha2a receptor is expressed in the brain, spleen, kidney, heart and gastrointestinal tract. It is centrally predominant and exerts a tonic sympathoinhibitory function, whereas peripherally it has a vasoconstrictive effect. The alpha2a receptor is also involved in sedation, digestive functions and analgesia.

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Human ADRA1B-FLAG Stable Cell Line-CHO REST Us
Categories:
PASSED
Norepinephrine is implicated in a wide range of physiological processes through activation of nine different G-protein-coupled receptors (alpha1a, alpha1b, alpha1d, alpha2a, alpha2b, alpha2c, beta1, beta2, beta3). The alpha1B-adrenoceptor expresses in brain, heart, kidney, and artery of various mammalian species and mediate diverse effects on cardiac functions, muscle contractions and cell growth.

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Human ADORA3-FLAG Stable Cell Line-HEK293T REST Us
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PASSED
Adenosine A3 receptors are involved in a variety of intracellular signaling pathways and physiological functions. They are expressed in a wide range of human tissues, but most predominantly in the lung and liver. Recent animal model studies have shown that A3 receptors play important roles in brain ischemia, immunosuppresion, and bronchospasm. A3 receptor agonists and/or agonists may have important clinical value in the treatment of asthma and inflammation.

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Human ADORA2B-FLAG Stable Cell Line-HEK293T REST Us
Categories:
PASSED
A2B is a receptor for adenosine. A2B receptor is upregulated during intestinal inflammation and mediates key events such as chloride, IL-6 and fibronectin secretion in intestinal epithelial cells. A2B receptor antagonists may have important clinical value in the treatment of inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), as well as inflammatory bowel disease.

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Human ADORA2A-FLAG Stable Cell Line-CHO REST Us
Categories:
PASSED
Adenosine regulates the function of the innate and adaptive immune systems through targeting virtually every cell type that is involved in orchestrating an immune/inflammatory response. Of the four adenosine receptors (A1, A2A, A2B, A3), A2A receptor is the primary anti-inflammatory effectors of extracellular adenosine. A2A receptor predominant expresses in monocytes/macrophages, dendritic cells, mast cells, neutrophils, endothelial cells, eosinophils, epithelial cells, as well as lymphocytes...

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Human ADORA1-FLAG Stable Cell Line-CHO REST Us
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PASSED
Adenosine A1 receptor (ADORA1 or RDC7) is a G protein-coupled receptor for adenosine. RT-PCR detected A1 expression in the brain, colon, jejunum, ileum and kidney. A1 functions in sleep-wake regulation and the fertilization process.

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Human CHRM5 Stable Cell Line-CHO REST Us
PASSED
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulati...

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Human SSTR1 Stable Cell Line-CHO REST Us
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PASSED
Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the ...

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Human O3FAR1 Stable Cell Line-CHO REST Us
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PASSED
This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene.

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Human CHRM2 Stable Cell Line-CHO REST Us
PASSED
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in me...

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Human CHRM1 Stable Cell Line-CHO REST Us
Categories:
PASSED
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-...

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Human FFAR2 Stable Cell Line-CHO REST Us
PASSED
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels.

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Human OPRL1 Stable Cell Line-CHO REST Us
PASSED
The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. ...

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Human GCGR Stable Cell Line-CHO REST Us
PASSED
The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).

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Human HRH2 Stable Cell Line-CHO REST Us
PASSED
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternative...

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Human CHRM3 Stable Cell Line-CHO REST Us
Categories:
PASSED
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction a...

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Human FFAR3 Stable Cell Line-CHO REST Us
PASSED
Free fatty acid receptor 3 (FFA3) is a G-protein coupled receptor that in humans is encoded by the FFAR3 gene. Receptor for short chain fatty acids. The activity of this receptor is coupled to the formation of inositol 1,4,5-trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/2 and inhibition of intracellular cAMP accumulation. Coupled exclusively to the pertussis toxin-sensitive G(i/o)-alpha protein. The rank order of potency for agonists of this receptor is propionate = ...

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