Web Service Human KCNQ2/KCNQ4 Stable Cell Line-CHO REST Us

aka Human KCNQ2/KCNQ4 Stable Cell Line-CHO Add_annotation_inactiveAdd_annotation_inactiveLog in to add alternative_name
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Annotations: 5 Total number of annotations from the provider's definition / description document. 0 Total number of annotations submitted by members of BioCatalogue. 5 Total number of annotations sourced from other registries. 0

Overview

Provider:
www-creative-bioarray-com

Location:
United States Us

Submitter/Source:
Bennie GeorgeUs (16 days ago)

Base URL:
https://www.creative-bioarray.com/acroscell/human-kcnq2-kcnq4-stable-cell-line-cho-acc-ri0146-item-64.htm

Description(s):
by Bennie George (16 days ago)

The human KCNQ2 and KCNQ4 genes encode the pore-forming subunits of Kv7.2 and Kv7.4, respectively. These subunits form heteromeric voltage-gated potassium channels that underlie M-current that regulates repetitive activity in neurons. Mutations in KCNQ2 that reduce M-current are responsible for some forms of benign familial neonatal seizure. KCNQ4 loss-of-function mutations cause hereditary deafness. Kv7.2/Kv7.4 channels are therapeutic targets in seizure and neuropathic pain.

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