European Bioinformatics Institute (EBI)


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Hamish McWilliam (11 months ago)

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Documentation URL(s): Hamish McWilliam (11 months ago)

Login to add a documentation URL Description(s): Hamish McWilliam (11 months ago)This is the REST version of the service, for the document/literal SOAP version of the service see

Hamish McWilliam (11 months ago)PRANK is a probabilistic multiple alignment program for DNA, codon and amino-acid sequences. It’s based on a novel algorithm that treats insertions correctly and avoids over-estimation of the number of deletion events. In addition, PRANK borrows ideas from maximum likelihood methods used in phylogenetics and correctly takes into account the evolutionary distances between sequences. Lastly, PRANK allows for defining a potential structure for sequences to be aligned and then, simultaneously with the alignment, predicts the locations of structural units in the sequences.

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Login to add contact info Publications: for this service. This can be a URI to the publication and/or a DOI. Hamish McWilliam (2 days ago)Goujon M., McWilliam H., Li W., Valentin F., Squizzato S., Paern J. and Lopez R. (2010)
“A new bioinformatics analysis tools framework at EMBL-EBI.”
Nucleic Acids Res. 38:W695-9
PMID: 20439314 (;=MED)
DOI: 10.1093/nar/gkq313 (

Hamish McWilliam (2 days ago)Löytynoja A. and Goldman N. (2005).
“An algorithm for progressive multiple alignment of sequences with insertions.”
PNAS 102:10557-10562.
PMID: 16000407 (;=MED)
DOI: 10.1073/pnas.0409137102 (

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